Wet AMD|Efficacy|3-Line Gains

3-line gains may be a reality with LUCENTIS^®1

LUCENTIS is the first and only therapy proven to deliver a 3-line gain in up to 41% of wet AMD patients in 2 years¹

Wet AMD patients achieved VA scores of 20/40 with LUCENTIS²

Up to 42% of LUCENTIS-treated wet AMD patients achieved VA of 20/40 or better at year 2²

An unprecedented 6-line gain with LUCENTIS was achieved in up to 14% of patients²

At year 2, 6% of wet AMD patients in MARINA and 14% of patients in ANCHOR had gained >6 lines (vs 0.4% with sham and 2% with verteporfin PDT), respectively. 3% and 0% of LUCENTIS-treated patients lost >6 lines (vs 23% with sham and 16% with verteporfin PDT)

INDICATION

LUCENTIS^® (ranibizumab injection) is indicated for the treatment of patients with:

Neovascular (Wet) Age-Related Macular Degeneration (AMD)
Macular Edema Following Retinal Vein Occlusion (RVO)

IMPORTANT SAFETY INFORMATION

LUCENTIS is contraindicated in patients with ocular or periocular infections or hypersensitivity to ranibizumab or any of the excipients in LUCENTIS.

WARNINGS AND PRECAUTIONS
Intravitreal injections, including those with LUCENTIS, have been associated with endophthalmitis, retinal detachment, and iatrogenic traumatic cataract. Proper aseptic injection technique should always be utilized when administering LUCENTIS. Patients should be monitored during the week following the injection to permit early treatment, should an infection occur.

Increases in intraocular pressure (IOP) have been noted within 60 minutes of intravitreal injection. IOP and perfusion of the optic nerve head should be monitored and managed appropriately.

Although there was a low rate of arterial thromboembolic events (ATEs) observed in the LUCENTIS clinical trials, there is a potential risk of ATEs following intravitreal use of VEGF inhibitors. ATEs are defined as nonfatal stroke, nonfatal myocardial infarction, or vascular death (including deaths of unknown cause).

ADVERSE EVENTS
Serious adverse events related to the injection procedure occurring in <0.1% of intravitreal injections included endophthalmitis, rhegmatogenous retinal detachment, and iatrogenic traumatic cataract.

In neovascular (wet) age-related macular degeneration clinical trials, most common ocular side effects included conjunctival hemorrhage, eye pain, vitreous floaters, vitreous detachment, and intraocular inflammation. Most common non-ocular side effects included nasopharyngitis, headache, arthralgia, and bronchitis.

In macular edema following retinal vein occlusion clinical trials, most common ocular side effects included conjunctival hemorrhage, eye pain, and maculopathy. Most common non-ocular side effects included nasopharyngitis, headache, influenza, and sinusitis.

For additional safety information, please see LUCENTIS full prescribing information

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